… Prototypical D3R preferring antagonists with D2 receptorial actions, such as nafadotride …
visualization/imaging of D3R and its in vivo occupancy following drug treatment. Obviously, [ 11 …

… by nafadotride, a partially selective D3 receptor antagonist, at low … ) and measurement of in
vivo D3 receptor occupancy in rats, … It was suggested that higher D3 receptor occupancy may …

… Nafadotride is usually considered a highly potent and competitive, centrally active D 3 DR
antagonist (… Functional correlates of dopamine D3 receptor activation in the rat in vivo and their …

… also have high affinity for the dopamine D 3 receptor (D3R) (8… distinguish between D2R
and D3R occupancy (9). Though … -biased SGA to an ex vivo slice of mouse PFC modulates Ca …

… In humans, in vivo imaging of D2-like receptors with [ 11 C] … with D3R, D3nf decreases the
capacity of D3R to interact with … (ST 198) and less specific (nafadotride) D3R antagonist also …

The dopamine D3 receptor (D3R) plays a prominent role in the modulation of cognition in
healthy individuals, as well as in the pathophysiological mechanism underlying the cognitive …

… Effects of dopamine D3 receptor antagonists on spontaneous … rats: comparative study with
nafadotride, U 99194A and SB … In vivo occupancy of dopamine D3 receptors by antagonists …

… -related loci in the genetic studies or (ii) the differential captation of nuclear medicine tracers
for imaging of the dopaminergic system (DAT, dopamine receptors and enzymes) in the …

… For instance, our group examined the D2/3 receptor occupancy of buspirone, indicated
for … In vivo occupancy studies in humans using a highly selective D3 antagonist to block [C-11]-(…

… the dopaminergic system to treat substance use disorders. Dopamine has 5 receptor subtypes
(… Given the localization and safety profile of the dopamine receptor D3 (DRD3), it is of …